3.step three. Exposure Situations

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Each other Bmi and you can weight had been correlated with BMD, and you can BMC evidence plus the strongest Pearson’s correlation coefficients was in fact discovered between weight and you will BMC as a whole hip and you may trochanter regions and the weakest of those had been anywhere between Bmi and femoral shoulder BMC. The fresh new correlations between many years and BMD and you can BMC indications was in fact bad (Desk 4).

The age-adjusted ratio from BMD and you can BMC variation told me of the Body mass index and lbs is actually revealed inside Table 5. Lbs tended to let you know higher variations in BMD and you may BMC shipment anyway this new analyzed skeletal internet versus Bmi. It was mirrored by steeper hill (?) of respective linear regression contours. The most effective difference in BMD and you may BMC shipment looked at the trochanter BMC accompanied by lumbar BMC to own pounds eros escort. Weight is an important predictor regarding BMD and BMC type inside old Iranian guys.

4. Talk

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The newest components whereby fat exerts results to your BMD updates commonly totally obvious. The brand new putative apparatus relevance away from adipose tissue getting skeletal stability most likely stays in the newest character of numerous adipokines in the bone renovations because of impact on both development and you can resorption. Recently, bones could have been felt a keen endocrine body organ affecting lbs control and you will sugar homoeostasis from measures out-of limbs-derived situations like osteocalcin and you will osteopontin [23, 34–36]. Brand new putative crosstalk ranging from pounds therefore the bones constitutes an effective homoeostatic views program in which adipokines and you will molecules secreted from the osteoblasts and you can osteoclasts portray the web link of an energetic bones-adipose axis [34–36]. Obesity is even with the BMD by transformation out of androgen to estrogen , and that enhances bones bulk both in someone [38, 39] and you may holds compliment plasma degrees of insulin and you will controlling items including insulin-such as for example increases grounds-step 1, leptin, and you can adiponectin . Additionally, carrying excess fat provides padding to your hip in the event of a beneficial fall . But not, the systems wherein all of these occurrences can be found continue to be unsure.